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Guidelines for Safe Handling of Cytotoxic Drugs
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Procedure for donning protective clothing for preparation of chemotherapy drugs
Procedure for removing protective clothing after preparation of chemotherapy drugs
Procedure for managing cytotoxic spill 
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Appendix
Preparation Aspects
 

Procedure for managing cytotoxic spill

A. Scope.
    This appendix defines standard procedure for managing spill.

B. Procedure for managing spill in the cabinet.
    The procedure should be as follows:

1.
Ensure that the cabinet remains operating
2.

Absorb liquid spill with absorbent pads and dispose them into a sealable bag
3.

Absorb powder spill with wet towels and dispose them into a sealable bag
4.
Wash the entire area with detergent solution
5.
Rinse well with clean water
6.

Repeat washing and rinsing until all of the drug has been removed
7.
Discard all contaminated items into a sealable waste bag.
8.

Remove outer pair of gloves and dispose them into a sealable waste bag
9.

Discard all sealed waste bags and contaminated items into a cytotoxic waste bag or bin
10.

Remove protective clothing and discard into cytotoxic disposal waste bag
11.
Wash hands thoroughly
12.
Fill up the incident report form as required by your work place


C. Procedure for managing spill outside the cabinet.
    The procedure should be as follows:
1.

Call for assistance if necessary. Do not leave the area unattended.
2.
Don protective clothing:
 
- Gown
 
- Shoe cover
 
- Gloves
 
- Respirator
 
- Chemical safety glasses
 
- Chemotherapy gloves
3.

Remove glass particles and other debris using the absorbent pads. Place them in the appropriate sharps container
4.

Absorb liquid spill with absorbent pads and dispose them into a sealable bag
5.

Absorb powder spill with wet towels and dispose them into a sealable bag
6.
Wash the entire area with detergent solution
7.
Rinse well with clean water
8.

Repeat washing and rinsing until all of the drug has been removed
9.
Discard all contaminated items into a sealable waste bag.
10.

Remove outer pair of gloves and dispose them into a sealable waste bag
11.

Discard all sealed waste bags and contaminated items into a cytotoxic waste bag or bin
12.

Remove remaining protective clothing and discard into cytotoxic disposal waste bag
13.
Wash hands thoroughly
14.
Fill up the incident report form as required by your work place
 
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  Is regular full blood profile useful for staff exposure monitoring?  
Is the use of isolator better than class II cytotoxic drug cabinet for the preparation of cytotoxic drugs?
   
  

 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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